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First presenting with hyperpigmentation-like caf-au-lait macules and freckling in afflicted patients, the hallmark of NF1 is the development of neurofibromas, benign tumors composed of an admixture of dysplastic Schwann cells and stromal cells, including fibroblasts, mast cells, and perineural cells embedded in a collagenous extracellular matrix (ECM)

B12 is essential for red blood cell production, neurological function, and cellular energy metabolism

Furthermore, we posit that cancer cells that are intrinsically resistant to redox modulation facilitate a cellular state in which observations of the p53 mutant-specific rescue effects of APR-246 can be observed

(+)- tocopherol succinate (-TOS), a succinate ester of (+)- tocopherol, can induce apoptosis of NB4, NB4-R2 (ATRA-resistant) and primary APL cells

In contrast, FoB exhibit lower intracellular ROS and maintain a metabolic setup that is distinct from that in MZB

The first family of polyamidoamine dendrimers (PAMAM) were synthesized by Tomalia et al